2015-03-10A Polymorphism in IRF4 Affects Human Pigmentation through a Tyrosinase-Dependent MITF/TFAP2A Pathway

标签:polymorphismIRF4

Sequence polymorphisms linked to human diseases and phenotypes in genome-wide association studies often affect noncoding regions. ...

2015-03-10Structural Basis for DNA Binding Specificity by the Auxin-Dependent ARF Transcription Factors

标签:DNA

Auxin regulates numerous plant developmental processes by controlling gene expression via a family of functionally distinct DNA-binding auxin response factors (ARFs), yet the mechanistic basis for generating specificity in auxin response is unknown. ...

2015-03-10Chemokine Receptor 7 (CCR7) Gene Expression Is Regulated by NF-{kappa}B and Activator Protein 1 (AP1)

标签:CancerCCR7

The chemokine receptor CCR7 is a seven-transmembrane domain G-protein-coupled receptor that facilitates leukocyte migration to regional lymph nodes. ...

2015-03-10Liver X Receptor α Is Involved in the Transcriptional Regulation of the 6-Phosphofructo-2-Kinase_Fru

标签:Regulation

The activity of 6-phosphofructo-1-kinase is strictly controlled by fructose-2,6-bisphosphate, the level of which is regulated by another enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK2/FBP2). ...

2015-03-10PLK1 Signaling in Breast Cancer Cells Cooperates with Estrogen Receptor-Dependent Gene Transcription

标签:Cell Reports

Polo-like kinase 1 (PLK1) is a key regulator of cell division and is overexpressed in many types of human cancers. ...

2014-08-182014年8月13日Cell Host & Microbe期刊封面亮点

标签:疟原虫表观遗传因子异染色质蛋白

2014年8月13日Cell Host & Microbe期刊封面描述人工吉母萨染色的血涂片和HP1/Hda2耗尽寄生虫的配子母细胞hyperconversion表型(狭长/月牙形状)。...

2014-08-11Neuron:移植的干细胞在脊髓损伤的大鼠模型中快速生长

标签:大鼠神经元轴突iPSC

美国加州大学圣地亚哥分校等处的研究人员利用人类诱导多能干细胞(iPSC),重编程为神经元,然后将它们移植到脊髓损伤大鼠体内生成了具有轴突的细胞。这些结果表明,内在神经元机制可以轻...

2014-08-11Cell Reports:伦敦大学揭示人类肠道干细胞的行为机制

标签:肠道干细胞

伦敦大学玛丽女王学院的研究人员通过研究首次发现了人类肠道中干细胞的行为机制,或为肠癌的早期发现以及预防措施提供一定的思路和帮助。...

2014-08-06Cell盘点近期人类微生物组研究进展

标签:Cell人类微生物组

上周四Cell杂志发表一篇近期关于人类微生物组的研究盘点,指出,人体微生物组具有多方面特征,不同的微生物菌群,不同的位置也会影响这些微生物的生活。...